Rare Cancer News & Clinical Trials

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Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review.

Fetched: September 1st, 2010, 9:30am CDT

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review.

Langenbecks Arch Surg. 2010 Aug 28;

Authors: Butturini G, Pisano M, Scarpa A, D'Onofrio M, Auriemma A, Bassi C

PURPOSE: Acinar cell carcinomas (ACCs) are a rare pancreatic tumor group with no standardized treatment. The aim of the study is to analyze the clinical and pathologic characteristics of our series and to review the current literature. METHODS: Retrospective review of prospectively collected data from 1990 to 2007 included patients who underwent pancreatic resection for histologically proven ACCs. All specimens of ACC were rereviewed by an expert pathologist. Follow-up was updated to October 2009. A literature search was performed by Pubmed and COCHRANE library. RESULTS: Among 1,210 patients who underwent pancreatic resection, we identified nine ACCs. R0 resection was possible for all but one R1. We had no major complications and no mortality. All nine cases were diagnosed as pure ACCs. Five patients received adjuvant chemotherapy. Median overall survival was 31 months, while median disease-free survival was 18 months. All patients developed liver metastases, requiring modification of chemotherapeutic schema, radiofrequency ablation techniques, or reiterate surgery. Currently, only one patient is alive without evidence of disease 85 months after pancreatic resection. One patient is alive 52 months after operation, with evidence of recurrent disease. CONCLUSIONS: ACC represents a rare solid tumor of the pancreas. Prognosis is dismal, although, compared to the more common ductal adenocarcinoma, survival appears to be longer. Patients with metastatic disease might benefit from aggressive multimodality treatments.

PMID: 20803029 [PubMed - as supplied by publisher]

Functional Pancreatic Acinar Cell Carcinoma Extending into the Main Pancreatic Duct and Splenic Vein.

Fetched: August 17th, 2010, 9:13am CDT

Functional Pancreatic Acinar Cell Carcinoma Extending into the Main Pancreatic Duct and Splenic Vein.

J Gastrointest Cancer. 2010 Aug 12;

Authors: Iwatate M, Matsubayashi H, Sasaki K, Kishida N, Yoshikawa S, Ono H, Maitra A

INTRODUCTION: Pancreatic acinar cell carcinoma (ACC) has several unique characteristics, such as its progression pattern, spreading into the pancreatic duct and large blood vessels, and its secretion of pancreatic exocrine enzymes, which induces a paraneoplastic syndrome. CASE REPORT: A 79-year-old Japanese man, with medical history of chronic renal failure, was referred to our institution for the examination of his abdominal pain and hyperglycemia. Plain computed tomography demonstrated a mass lesion, 4 cm in diameter, in the body of pancreas. Abdominal ultrasonogram demonstrated a bulky, hypoechoic mass extending into the splenic vein. Multiple hepatic nodules were detected on suspicion of metastasis. Positron emission tomography using 18F-fluorodeoxyglucoase revealed the tumor extended towards the pancreatic head through the main pancreatic duct. We obtained the tumor tissues from the pancreatic body using endoscopic ultrasound-guided fine-needle aspiration biopsy. Pathological diagnosis, supported by immunohistochemistry, was that of an ACC. In the follow-up period, he complained of subcutaneous nodules and arthralgia on his lower legs. Serum and intra-articular lipase levels were elevated, 6,420 I/U and 594 I/U, respectively. Histology of the skin lesion at the knee joint showed necrotizing panniculitis with eosinophilic infiltration. The patient was treated with weekly gemcitabine, but succumbed to acute respiratory distress unexpectedly 2 months after the initial diagnosis.

PMID: 20703831 [PubMed - as supplied by publisher]

Imaging findings in a case of mixed acinar-endocrine carcinoma of the pancreas.

Fetched: August 17th, 2010, 9:13am CDT

Imaging findings in a case of mixed acinar-endocrine carcinoma of the pancreas.

Korean J Radiol. 2010 May-Jun;11(3):378-81

Authors: Chung WJ, Byun JH, Lee SS, Lee MG

Mixed acinar-endocrine carcinoma (MAEC) of the pancreas is extremely uncommon. We report here a rare case of MAEC of the pancreas presenting as watery diarrhea. This is the first report in the English-language literature that describes the imaging findings of MAEC of the pancreas, including computed tomography (CT), magnetic resonance (MR) imaging, and MR cholangiopancreatography features.

PMID: 20461195 [PubMed - indexed for MEDLINE]

Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.

Fetched: August 17th, 2010, 9:13am CDT

Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.

Diagn Cytopathol. 2010 Jun;38(6):430-4

Authors: Fulciniti F, Losito NS, Botti G, Manola M, Ionna F

Ischemic or hemorrhagic infarction has been described as an uncommon but possible complication of fine-needle cytology sampling in numerous organs, more frequently the thyroid, the salivary glands, the breast, the lymph node, and the kidney. In these situations, infarction appears to be directly related to the vascular disturbances caused by needle sampling, though fine this latter might be. One case of a spontaneous infarction of a parotid pleomorphic adenoma in a 46-year-old lady is here described in which the cytopathologic findings, which were related to ischemic infarction, preceded fine-needle cytology sampling and mimicked malignancy. The cytopathologic picture showed a quizzical mixture of necrosis and inflammation coupled to hyperplastic changes of the acinar cells, oncocytic metaplasia, and atypical squamous metaplasia of extreme degree simulating high-grade epidermoid- or mucoepidermoid carcinoma. Due to the cytologically suggestive changes, a nerve-sparing radical parotidectomy was performed. The differential diagnostic problems encountered in this case are discussed together to the possible medical-legal implications originating from such striking atypias as to closely simulate malignancy.

PMID: 19894261 [PubMed - indexed for MEDLINE]

A case of acinar cell carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration prior to surgical treatment.

Fetched: August 10th, 2010, 6:31pm CDT

A case of acinar cell carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration prior to surgical treatment.

Nippon Shokakibyo Gakkai Zasshi. 2010 Aug;107(8):1328-34

Authors: Mataki Y, Shinchi H, Kurahara H, Maemura K, Minami K, Setoyama T, Ueno S, Sakoda M, Yamamoto T, Takao S, Natsugoe S

A 65-year-old woman was admitted with upper abdominal pain and pyrexia. She was given a diagnosis of acute pancreatitis and treated with intravenous infusion. After recovering, abdominal enhanced-CT showed a low density area in the head of the pancreas, measuring 2cm in maximum dimension. Endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) revealed acinar cell carcinoma (ACC). She underwent curative subtotal stomach-preserving pancreaticoduodenectomy. The definitive diagnosis, based on the histopathological examinations including immunohistochemical staining, was ACC. ACC of the pancreas is extremely rare, occurring in approximately 1% of all cases of pancreatic neoplasm. We report a rare case diagnosed as ACC by EUS-FNA prior to surgical treatment.

PMID: 20693758 [PubMed - in process]

[Clinical and pathological analysis of 114 cases with non-ductal pancreatic adenocarcinoma occupying lesions]

Fetched: August 4th, 2010, 9:26am CDT

[Clinical and pathological analysis of 114 cases with non-ductal pancreatic adenocarcinoma occupying lesions]

Zhonghua Yi Xue Za Zhi. 2010 Apr 27;90(16):1089-92

Authors: Wang Y, Xie SL, Wang CF, Liu SM, Shan Y, Zhao DB, Liu Q, Luo W, Zhao P

OBJECTIVE: To improve the diagnosis and treatment of non-ductal pancreatic adenocarcinoma-occupying lesions. METHODS: A retrospective analysis was made for 114 cases of pancreatic non-ductal adenocarcinoma-occupying pathologically confirmed lesions. RESULTS: (1) There were 36 males (31.6%) and 78 females (68.42%); (2) presenting symptoms and signs were abdominal pain (n = 56, 49.1%), back pain (n = 24, 21.1%), weight loss (n = 18, 15.8%) and obstructive jaundice (n = 8, 0.07%); (3) the positive rates of CA19-9, CA242 and CEA were 21.1%, 19.7% and 5.6% respectively; (4) pancreaticoduodenectomy was performed in 26 patients, distal pancreatectomy in 53, tumor enucleation in 15, segmental pancreatectomy in 9, partial resection in 3, duodenum-preserving pancreatic head resection in 1 and palliative surgery (either cholecystojejunostomy anastomosis or gastrojejunostomy) in 7; (5) pathologic analysis revealed 35 solid pseudopapillary neoplasm of pancreas, 28 pancreatic endocrine tumors, 18 focal chronic pancreatitis, 11 serous cystic neoplasms, 9 mucinous cystic neoplasms, 4 pancreatic cysts, 3 acinar cell carcinomas, 2 pancreatic cavernous hemangiomas, 1 sarcoma of pancreas, 1 sarcomatiod carcinoma of pancreas, 1 pancreatic schwannnoma and 1 pancreatic neuroblastoma. CONCLUSION: The non-ductal pancreatic adenocarcinoma-occupying lesions have no specific clinical presentation or serum tumor marker. An understanding of the natural history of these lesions is important for optimal management.

PMID: 20646423 [PubMed - in process]

Mayo Clinic Experience With Very Rare Exocrine Pancreatic Neoplasms.

Fetched: August 4th, 2010, 9:26am CDT

Mayo Clinic Experience With Very Rare Exocrine Pancreatic Neoplasms.

Pancreas. 2010 Jul 7;

Authors: Mansfield A, Tafur A, Smithedajkul P, Corsini M, Quevedo F, Miller R

OBJECTIVES:: Limited data are available to guide the management of very rare exocrine neoplasms of the pancreas (VREP). Available evidence suggests that VREP have different risk factors and prognoses from those of adenocarcinoma of the pancreas. The primary objectives for this study were to determine the survival, comorbidities, and response to treatment of patients seen at Mayo Clinic with VREP. METHODS:: We reviewed patients from 1975 to 2005 who had VREP and compared them to patients with adenocarcinomas that were matched for TNM, grade, and decade of treatment. RESULTS:: Sixty-six patients with VREP were identified. The most commonly identified neoplasms were acinar cell carcinoma (n = 15), small cell carcinoma (n = 12), and squamous cell carcinoma (n = 8). Abdominal discomfort and jaundice were the most common presenting symptoms. The median overall survival for patients with VREP, 10.4 months (range, 3.7-23 months), was better than that for matched controls, 8.2 months (range, 4-15.4 months) (P = 0.01). There was no difference in the survival of patients with stage 4 disease between cases, 8 months (range, 2.3-21.8 months), and controls, 6.7 months (range, 2.3-10.8 months) (P = 0.17). CONCLUSIONS:: We present one of the largest series of VREP to date. The overall survival of all patients with VREP was better than matched controls, but no statistical difference was seen between the groups with stage 4 disease.

PMID: 20622706 [PubMed - as supplied by publisher]

Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma.

Fetched: August 4th, 2010, 9:26am CDT

Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma.

Int J Environ Res Public Health. 2010 Mar;7(3):1093-104

Authors: Gerloff A, Singer MV, Feick P

In this article we provide an overview of the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. Some non-alcoholic compounds of beer, such as quercetin, resveratrol, ellagic acid or catechins, have been shown to be protective against experimentally induced pancreatitis by inhibiting pancreatic secretion, stellate cell activation or by reducing oxidative stress. Quercetin, ellagic acid and resveratrol also show anti-carcinogenic potential in vitro and in vivo. However, beer contains many more non-alcoholic ingredients. Their relevance in beer-induced functional alterations of pancreatic cells leading to pancreatitis and pancreatic cancer in humans needs to be further evaluated.

PMID: 20617020 [PubMed - in process]

Permalink for 'Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case.'

Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case.

Fetched: August 4th, 2010, 9:26am CDT

Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case.

Surg Today. 2010 Jul;40(7):679-83

Authors: Suzuki A, Sakaguchi T, Morita Y, Oishi K, Fukumoto K, Inaba K, Takehara Y, Baba S, Suzuki S, Konno H

Acinar cell carcinoma is a relatively rare malignant neoplasm, which represents 1%-2% of all pancreatic exocrine tumors. Its prognosis is thought to be poor, especially when it metastasizes to the liver. This report concerns a case of a long-term survivor of metastatic acinar cell carcinoma who was successfully treated with repetitive surgery. A 62-year-old man underwent a distal pancreatectomy for a pancreatic tumor, which was histologically diagnosed as an acinar cell carcinoma. The tumor recurred in the liver three times within 41 months. At the first recurrence, four hepatic lesions appeared 7 months after the initial pancreatectomy and were managed with an extended left hepatic lobectomy and partial liver resection. Thereafter, a solitary nodule in Segment 6 was identified 21 months after the second surgery and was treated with a partial liver resection. A solitary lesion in Segment 8/5 appeared 11 months after the third surgery and was also managed by a partial liver resection. The patient has remained disease-free for 22 months since the last surgery and has survived 65 months since the initial diagnosis. Although no consensus has been reached on surgery for metastatic acinar cell carcinoma, the current case has important implications for establishing an appropriate treatment strategy.

PMID: 20582524 [PubMed - in process]

Permalink for 'Prognostic relevance of CA 19-9, CEA, CRP, and LDH kinetics in patients treated with palliative second-line therapy for advanced pancreatic cancer.'

Prognostic relevance of CA 19-9, CEA, CRP, and LDH kinetics in patients treated with palliative second-line therapy for advanced pancreatic cancer.

Fetched: August 4th, 2010, 9:26am CDT

Prognostic relevance of CA 19-9, CEA, CRP, and LDH kinetics in patients treated with palliative second-line therapy for advanced pancreatic cancer.

Tumour Biol. 2010 Aug;31(4):351-7

Authors: Haas M, Laubender RP, Stieber P, Holdenrieder S, Bruns CJ, Wilkowski R, Mansmann U, Heinemann V, Boeck S

The objective of this study was to define prognostic serum biomarkers that could serve as surrogate survival endpoints during second-line treatment for advanced pancreatic cancer. This retrospective single-center study included patients treated with second-line therapy for advanced exocrine pancreatic cancer. A pretreatment value and at least one serial measurement during the first two cycles of second-line chemotherapy for CA 19-9, CEA, CRP, and LDH had to be available in order to evaluate the prognostic role of kinetics on overall survival. A cutoff of a >20% increase from baseline during treatment was defined in order to form groups with suspected different outcomes. The effect of serial biomarker changes on survival was modeled by Cox proportional hazards regression in univariate and multivariate analyses. Overall, 70 patients treated with second-line therapy for advanced disease were included; 94% had distant metastases at treatment initiation. Median time to progression was 2.7 months and median survival 5.4 months. Univariate analysis found that an increase of >20% during treatment was significantly associated with a worse overall survival for CA 19-9 (HR 2.00, p = 0.018), CEA (HR 2.38, p = 0.004), and CRP (HR 3.06, p < 0.001). These associations remained significant within multivariate analysis for CEA (HR 2.86, p = 0.001) and CRP (HR 3.20, p = 0.001). Serum biomarker kinetics might serve as useful prognostic tools during second-line chemotherapy in advanced pancreatic cancer.

PMID: 20480409 [PubMed - indexed for MEDLINE]

Rare histological patterns of prostatic ductal adenocarcinoma.

Fetched: August 4th, 2010, 9:26am CDT

Rare histological patterns of prostatic ductal adenocarcinoma.

Pathology. 2010 Jun;42(4):319-24

Authors: Lee TK, Miller JS, Epstein JI

AIMS: Prostatic ductal adenocarcinomas account for 1% of prostate cancers. Most commonly, these lesions grow in large cribriform and/or papillary patterns or, as recently described, in a manner resembling prostatic intraepithelial neoplasia (i.e., 'PIN-like' prostatic ductal adenocarcinoma). This study aims to report rare variants of ductal adenocarcinoma. METHODS: Ten cases of rare patterns of prostatic ductal adenocarcinoma that have not been formally investigated prior to this study, primarily from one author's consultation service (1987-2009), were selected. RESULTS: Two (n = 2) cases were prostatic ductal adenocarcinoma with mucinous and goblet cell features. Three (n = 3) cases are the first described cases of foamy gland prostatic ductal adenocarcinoma. Other unique cases were prostatic duct adenocarcinomas with associated Paneth cell-like neuroendocrine (n = 2), micropapillary (n = 2), and cystic papillary features (n = 1). Prostatic origin was confirmed with immunohistochemical studies for prostate specific antigen (PSA), P501S, and prostate specific membrane antigen (PSMA). High-grade PIN was ruled out with negative stains for high molecular weight cytokeratin (HMWCK) and p63. Four prostatic ductal adenocarcinomas had no evidence of disease at 2-8 years follow-up: foamy gland, Paneth cell-like, and micropapillary (two cases). One mucinous prostatic ductal adenocarcinoma resulted in the patient's death and the other mucinous case was alive at 7 years and 2 months, yet with no information as to status of disease. The remaining four cases were lost to follow-up, died of other causes, or were recent. CONCLUSIONS: In summary, we report several rare and unique histological patterns of prostatic ductal adenocarcinoma. The practical importance of recognising these histological variations is that in some cases they may be misdiagnosed as non-prostatic tumours. These unusual cases also provide further support for the relationship between acinar and ductal adenocarcinoma.

PMID: 20438402 [PubMed - indexed for MEDLINE]

Permalink for 'Distal pancreatectomy combined with celiac axis resection in treatment of carcinoma of the body/tail of the pancreas: a single-center experience.'

Distal pancreatectomy combined with celiac axis resection in treatment of carcinoma of the body/tail of the pancreas: a single-center experience.

Fetched: August 4th, 2010, 9:26am CDT

Distal pancreatectomy combined with celiac axis resection in treatment of carcinoma of the body/tail of the pancreas: a single-center experience.

Ann Surg Oncol. 2010 May;17(5):1359-66

Authors: Wu X, Tao R, Lei R, Han B, Cheng D, Shen B, Peng C

BACKGROUND: Few comparison studies have been carried out on patients with distal pancreatectomy (DP) combined with celiac axis (CA) resection. The aim of this study was to assess the safety and efficacy of this extended procedure in treatment of advanced carcinoma of the body/tail of the pancreas. METHODS: This was a retrospective analysis of 206 patients with carcinoma of the body/tail of the pancreas from January 2003 through June 2008. Patients were divided into three groups based on the relationship of tumor and CA/common hepatic artery (CHA) as well as different treatment strategies. Data for operation time, blood loss, complications, and survival time were collected and statistically analyzed. RESULTS: Sixty-five patients (31.6%) received radical distal pancreatectomy (DP), including 11 patients who underwent DP combined with celiac axis resection (group A) and 54 patients who received conventional DP (group B). Twenty patients did not undergo DP because of CA and/or CHA invasion only (group C). Group A had longer mean operative time than group B (323 versus 225 min, P = 0.000); there was no difference in mean estimated blood loss, percentage of pancreatic fistula or median survival time (14 versus 15 months, P = 0.197). However, group A had significantly prolonged median survival time compared with the 20 patients in group C (14 versus 5 months, P = 0.013), and quality of life was also dramatically improved. CONCLUSIONS: DP combined with CA resection can be safely performed in certain patients with carcinoma of body/tail of the pancreas and significantly improves patient survival and quality of life.

PMID: 20198445 [PubMed - indexed for MEDLINE]

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Fetched: August 4th, 2010, 9:26am CDT

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Skeletal Radiol. 2010 Jun;39(6):601-2

Authors: Takechi Y, Shinozaki T, Fukuda T, Asami K, Yanagawa T, Takagishi K

PMID: 20177674 [PubMed - indexed for MEDLINE]

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Fetched: August 4th, 2010, 9:26am CDT

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Skeletal Radiol. 2010 Jun;39(6):581-2, 601-2

Authors: Takechi Y, Shinozaki T, Fukuda T, Asami K, Yanagawa T, Takagishi K

PMID: 20174794 [PubMed - indexed for MEDLINE]

Permalink for 'Primary signet-ring carcinoma (SRC) of the lung: a population-based epidemiologic study of 262 cases with comparison to adenocarcinoma of the lung.'

Primary signet-ring carcinoma (SRC) of the lung: a population-based epidemiologic study of 262 cases with comparison to adenocarcinoma of the lung.

Fetched: August 4th, 2010, 9:26am CDT

Primary signet-ring carcinoma (SRC) of the lung: a population-based epidemiologic study of 262 cases with comparison to adenocarcinoma of the lung.

J Thorac Oncol. 2010 Apr;5(4):420-7

Authors: Ou SH, Ziogas A, Zell JA

BACKGROUND: The presence of signet-ring cell component has been described as a prominent feature of EML4-ALK positive non-small cell lung cancer. We investigated the clinicopathologic features and survival outcome of primary signet-ring carcinoma (SRC) of the lung with comparison to adenocarcinoma of the lung. METHODS: Retrospective population-based analysis of histologically diagnosed primary SRC of the lung in the California Cancer Registry between 1989 and 2006 with comparison with adenocarcinoma of the lung. RESULTS: Two hundred sixty-two histologically diagnosed primary SRC of the lung were compared to 50,089 patients with lung adenocarcinoma. Patients with primary SRC of the lung were significantly younger than patients with adenocarcinoma, with a significantly higher proportion of poorly differentiated tumor and stage IV disease. There was no difference in the distribution of gender and ethnicity among patients with SRC when compared to patients with adenocarcinoma. Subset analysis of patients with available smoking status revealed never smokers comprised a significantly higher proportion of patients with SRC (30.8%) when compared to patients with adenocarcinoma (11.0%; p = 0.0013). Never smokers with SRC tended to be younger with a trend to improved survival (median age = 55 years, median overall survival [OS] = 8 months) than ever smokers with SRC (median age = 59 years, median OS = 4.5 months). Patients with SRC had decreased OS (versus adenocarcinoma; unadjusted hazard ratio = 1.507; 95% confidence interval: 1.326-1.714; p < 0.0001) and was an independent unfavorable prognostic factor by multivariate analysis (versus adenocarcinoma, hazard ratio 1.214, 95% confidence interval: 1.068-1.381; p = 0.0030). CONCLUSIONS: Primary SRC of the lung is a rare subtype of adenocarcinoma, carries a worse prognosis when compared to adenocarcinoma and shares many of the recently identified clinicopathologic characteristics ascribed to EML4-ALK positive non-small cell lung cancer.

PMID: 20130484 [PubMed - indexed for MEDLINE]

Parotidectomies in benign parotid tumours: "Sant Pau" surgical extension classification.

Fetched: August 4th, 2010, 9:26am CDT

Parotidectomies in benign parotid tumours: "Sant Pau" surgical extension classification.

Acta Otorrinolaringol Esp. 2010 Jan-Feb;61(1):1-5

Authors: Quer M, Pujol A, LeÃ³n X, LÃ³pez M, GarcÃa J, OrÃºs C, SaÃ±udo JR

INTRODUCTION AND GOALS: At present different options co-exist for treating a benign tumour of the parotid gland, which has led to some confusion about the extent of resection performed in each case. In an effort to improve this situation, we created a classification system to define the areas removed. We started using this classification in July, 2006, and this article reviews its applicability and usefulness. METHODS: We analyzed 44 patients who underwent surgery for clinically benign tumours of the parotid gland in our department between July, 2006, and December, 2008. In all resections, our classification was applied, dividing the parotid gland into five areas: I (lateral superior), II (lateral inferior), III (deep superior), IV (deep inferior), V (accessory). RESULTS: The classification was easily applied and has presented no practical problem in the 44 patients operated. When analyzing the areas excised in surgery, the most common surgery was lateral inferior partial parotidectomy (removal of area II) in 47% of the cases. Lateral parotidectomy (removal of areas I and II) was the next most frequent, with 14 cases (33%). The remaining 20% was distributed among the other options. CONCLUSIONS: Our classification system appears to be a simple and easy way to define the surgery performed in each case, which simplifies the description of the resection performed, even in unusual resections.

PMID: 19962123 [PubMed - indexed for MEDLINE]

[Acinic cell carcinoma of the nasal septum]

Fetched: August 4th, 2010, 9:26am CDT

[Acinic cell carcinoma of the nasal septum]

Rev Stomatol Chir Maxillofac. 2010 Apr;111(2):88-90

Authors: Hammami B, Dhouib H, Sallemi M, Ben Hmida A, Ben Mahfoudh K, Daoud J, Ghorbel A

INTRODUCTION: Nasal cavity acinic carcinoma are exceptional and often of turbinal origin. We report a case of acinic carcinoma of septal origin and discuss this histological type rare in this site. OBSERVATION: A 47-year-old women, with no pathologic history, consulted for right nasal obstruction and hyposmia having evolved for a year. The clinical examination revealed a right nasal cavity lesion adhesive to the septum. Tomodensitometry showed a right nasal cavity and ethmoid opacity without bone destruction. The surgical treatment was endonasal tumor resection. The histological examination revealed a nasal fossa acinic carcinoma completely resected. A postoperative radiotherapy was initiated. The evolution was uneventful without recurrence after 4 years of follow-up. DISCUSSION: Acinic carcinoma is rarely located in the nasal cavity. Its septal origin is exceptional. It is usually located at the salivary gland level. Curative treatment is surgery associated or not to radiotherapy. The prognosis is related to tumor extension and quality of resection.

PMID: 19942241 [PubMed - indexed for MEDLINE]

Permalink for 'Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation.'

Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation.

Fetched: August 4th, 2010, 9:26am CDT

Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation.

Diagn Cytopathol. 2010 May;38(5):368-73

Authors: Fulciniti F, Losito NS, Ionna F, Longo F, Aversa C, Botti G, Foschini MP

Sclerosing polycystic adenosis (SPA) is a rare pathological condition affecting the salivary glands, first described by Smith etal. in 1996. Even though this lesion is being increasingly diagnosed, less than 50 cases have been published in the world literature to date. In line with numerous other pathological analogies between breast and salivary gland lesions, SPA shares with fibrocystic disease of the breast many histopathological features, i.e., fibrosis, oncocytic (apocrine) changes, hyperplasia of ductal and acinar epithelium, cystic dilation of ducts, and, often, atypical epithelial changes. Most of the described cases have followed a benign clinical course, despite the frequent possibility of atypical hyperplasia in more than 50% of the cases and of the more than occasional in situ malignant transformation. In this article, we introduce a new case occurring in the parotid gland of a 57-year-old male showing atypical epithelial hyperplasia and low-grade in situ mucoepidermoid carcinoma. Fine-needle cytology (FNC) was performed on the lesion and, when a diagnosis of SPA was prospected, the variegated cytological features of the obtained sample posed several differential diagnostic problems. The spectrum of pathological lesions entering differential diagnosis comprised sebaceous adenoma, Warthin's tumors with presence of sebaceous remnants, and low-grade mucoepidermoid carcinoma. Histopathological examination disclosed SCA with intraductal neoplastic transformation resembling noninvasive low-grade mucoepidermoid carcinoma. The cytological diagnosis of SPA should be entertained whenever a polymorphous picture is found on FNC samples comprising oncocytic/apocrine changes, sebaceous cells, cystic background, and epithelial hyperplasia with low-grade cytological atypias.

PMID: 19937766 [PubMed - indexed for MEDLINE]

Permalink for '[Correlation of early phase contrast enhancement of multi-detector row computed tomography to tumor stroma of nodular solid lung adenocarcinoma]'

[Correlation of early phase contrast enhancement of multi-detector row computed tomography to tumor stroma of nodular solid lung adenocarcinoma]

Fetched: August 4th, 2010, 9:26am CDT

[Correlation of early phase contrast enhancement of multi-detector row computed tomography to tumor stroma of nodular solid lung adenocarcinoma]

Ai Zheng. 2008 Nov;27(11):1190-6

Authors: Wang Y, Liu XG, Liang MZ, Qin PX, Lin YJ, Yi XP

BACKGROUND & OBJECTIVE: Dynamic enhanced multi-detector row CT (MDCT) has been used in differential diagnosis of pulmonary nodules, but its mechanism was unclear yet. This study was to evaluate the correlations of early phase enhancement of MDCT to proportion and distribution of stroma in solid lung adenocarcinoma. METHODS: A total of 31 patients with lung adenocarcinoma underwent routine contrast-enhanced MDCT. All lesions were solid solitary pulmonary nodules confirmed by pathology. CT observation items included net enhancement and distribution of enhancement. Tumor morphology was observed with HE staining. About 25 fields of view of each specimen at low magnification were scanned to obtain digital data. Semi-auto segmentation software was used to calculate mean stroma proportion. RESULTS: The proportion of invasive stroma in tumors was correlated positively to CT enhancement value (r=0.483, P=0.006). Of the 31 nodules, 18 (58.1%) showed homogenous enhancement, 10 (32.3%) showed peripheral inhomogenous enhancement, 1 (3.2%) showed central inhomogenous enhancement, 1 (3.2%) showed asymmetrical inhomogenous enhancement, 1 (3.2%) showed no enhancement; 18 (58.1%) nodules showed mixed distribution of stroma, 11 (35.5%) showed peripheral distribution, 1 (3.2%) showed central distribution, 1 (3.2%) showed asymmetrical distribution. Most acinar adenocarcinomas had net enhancement of > 20 Hu, which was significantly higher than that of solid adenocarcinomas with mucin subtype (P=0.005). CONCLUSIONS: Extent and pattern of CT enhancement of solid lung adenocarcinoma nodules reflect the proliferation and distribution of stroma, respectively. It is helpful to comprehend some false negative on CT enhancement by adequately understanding of the pathologic features of different subtypes of lung adenocarcinoma.

PMID: 19000452 [PubMed - indexed for MEDLINE]

Permalink for 'Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail.'

Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail.

Fetched: June 26th, 2010, 9:50am CDT

Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail.

Neoplasia. 2010 Mar;12(3):224-34

Authors: Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MC, Nemenoff RA

Work from our laboratory and others has demonstrated that activation of the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) inhibits transformed growth of non-small cell lung cancer (NSCLC) cell lines in vitro and in vivo. We have demonstrated that activation of PPARgamma promotes epithelial differentiation of NSCLC by increasing expression of E-cadherin, as well as inhibiting expression of COX-2 and nuclear factor-kappaB. The Snail family of transcription factors, which includes Snail (Snail1), Slug (Snail2), and ZEB1, is an important regulator of epithelial-mesenchymal transition, as well as cell survival. The goal of this study was to determine whether the biological responses to rosiglitazone, a member of the thiazolidinedione family of PPARgamma activators, are mediated through the regulation of Snail family members. Our results indicate that, in two independent NSCLC cell lines, rosiglitazone specifically decreased expression of Snail, with no significant effect on either Slug or ZEB1. Suppression of Snail using short hairpin RNA silencing mimicked the effects of PPARgamma activation, in inhibiting anchorage-independent growth, promoting acinar formation in three-dimensional culture, and inhibiting invasiveness. This was associated with the increased expression of E-cadherin and decreased expression of COX-2 and matrix metaloproteinases. Conversely, overexpression of Snail blocked the biological responses to rosiglitazone, increasing anchorage-independent growth, invasiveness, and promoting epithelial-mesenchymal transition. The suppression of Snail expression by rosiglitazone seemed to be independent of GSK-3 signaling but was rather mediated through suppression of extracellular signal-regulated kinase activity. These findings suggest that selective regulation of Snail may be critical in mediating the antitumorigenic effects of PPARgamma activators.

PMID: 20234816 [PubMed - indexed for MEDLINE]

Pancreatic Ducts as an Important Route of Tumor Extension for Acinar Cell Carcinoma of the Pancreas.

Fetched: June 15th, 2010, 3:51pm CDT

Pancreatic Ducts as an Important Route of Tumor Extension for Acinar Cell Carcinoma of the Pancreas.

Am J Surg Pathol. 2010 Jun 8;

Authors: Ban D, Shimada K, Sekine S, Sakamoto Y, Kosuge T, Kanai Y, Hiraoka N

Acinar cell carcinoma (ACC) of the pancreas is very rare, which usually grows expansively. Recently, a variant of ACC with predominant growth in the pancreatic ducts has been proposed, and is speculated to have potentially less aggressive behavior. The aim of this study was to investigate how the pancreatic duct system is related to the growth and extension of ACC. We reviewed the detailed gross and histologic features of 13 cases of ACC, of which 7 (54%) showed intraductal polypoid growth (IPG) of the tumor in the large pancreatic ducts with a mean IPG length of 24.8 mm. Tumors with IPG were found to spread characteristically along the pancreatic ducts as extending polypoid projections, filling the ducts and destroying the duct walls, although tumors did not tend to extend beyond the pancreatic parenchyma. Comparison of the clinicopathologic characteristics showed that ACC with IPG had less infiltrative features including lymphatic, venous, and neural invasion, formation of tumor thrombus in the portal vein, nodal metastasis, and invasion beyond the pancreas to the surrounding organs; death in only 1 case (14%) of ACC with IPG was the result of ACC itself. In contrast, ACC without IPG frequently showed more infiltrative growth, and was the cause of death in 50% of patients with this type of tumor. Intraductal dissemination of ACC in pancreatic ducts was proven in 1 case of ACC with IPG. These findings suggest that a significant proportion of ACC shows IPG, which is potentially linked to less aggressive clinicopathologic characteristics.

PMID: 20534994 [PubMed - as supplied by publisher]

[Hepatocellular carcinoma - from macroscopy to molecular pathology.]

Fetched: June 15th, 2010, 3:51pm CDT

[Hepatocellular carcinoma - from macroscopy to molecular pathology.]

Orv Hetil. 2010 Jun 13;151(24):982-9

Authors: Schaff Z, Kovalszky I, Lotz G, Kiss A

Hepatocellular carcinoma (HCC) is a tumor with rather bad prognosis. Recent years, however, have seen considerable progress in the diagnostics and treatment of this disease, contributing to better understanding of its molecular pathogenesis. Large regenerative nodules, low and high grade dysplastic nodules are premalignant alterations of HCC developing on the grounds of cirrhosis. Microscopically the WHO distinguishes trabecular, acinar (pseudoglandular), scirrhous and solid forms. Special histological subtypes are the clear cell, fibrolamellar and mixed hepato-cholangiocellular variants. The prognostic significance of these histological types is argued. The fibrolamellar, non-cirrhotic form of HCC occurring in young age is considered to be of better prognosis, but this is probably due to the fact that this type is not accompanied by cirrhosis. Certain tumor markers may help the diagnosis, such as alpha-fetoprotein (AFP), glypican-3, survivin, the recently described agrin and claudins, furthermore, the hepatocyte specific antigen (HSA), which confirms the hepatocytic origin of the tumor. Recently, the diagnostic significance of microRNAs, primarily of the hepatocyte-specific mir122 has also emerged. In addition to the Barcelona Clinic Liver Cancer (BCLC) staging classification which determines the course of therapy, the molecular classification of HCC is based on key molecular alterations, many of which are observable in all HCC cases, whereas some alterations are only detectable in certain tumors.

PMID: 20519181 [PubMed - in process]

Permalink for 'Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.'

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.

Fetched: June 15th, 2010, 3:51pm CDT

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.

J Mol Histol. 2009 Jun;40(3):189-99

Authors: Fu XM, Dai X, Ding J, Zhu BT

Members of the protein disulfide isomerase (PDI) family play a critical role in catalyzing the formation of disulfide bonds in secretory proteins, and most of these enzymes have a wide tissue distribution. However, the pancreas-specific PDI homolog was previously suggested to be exclusively expressed in the pancreas (thus commonly referred to as PDIp). In the present study, we found that PDIp was also highly expressed in several other tissues in mice, including the stomach, cecum, ileum, adrenal glands, epididymis, and prostate. Notably, in the digestive organs, such as the stomach and pancreas, very high levels of PDIp were selectively expressed in the digestive enzyme-secreting cells (e.g., gastric chief cells and pancreatic acinar cells). This observation suggests that PDIp may function as a protein-folding catalyst for secretory digestive enzymes. In ileum, PDIp was exclusively expressed in Paneth cells. In addition, high levels of PDIp expression were also detected in normal human pancreas, but its expression was mostly absent in human pancreatic duct adenocarcinoma and pancreatic cancer cell lines. The absence of PDIp expression in pancreatic adenocarcinoma may serve as an additional biomarker for pancreatic cancer.

PMID: 19821078 [PubMed - indexed for MEDLINE]

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review.

Fetched: September 1st, 2010, 9:30am CDT

Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review.

Langenbecks Arch Surg. 2010 Aug 28;

Authors: Butturini G, Pisano M, Scarpa A, D'Onofrio M, Auriemma A, Bassi C

PMID: 20803029 [PubMed - as supplied by publisher]

Functional Pancreatic Acinar Cell Carcinoma Extending into the Main Pancreatic Duct and Splenic Vein.

Fetched: August 17th, 2010, 9:13am CDT

Functional Pancreatic Acinar Cell Carcinoma Extending into the Main Pancreatic Duct and Splenic Vein.

J Gastrointest Cancer. 2010 Aug 12;

Authors: Iwatate M, Matsubayashi H, Sasaki K, Kishida N, Yoshikawa S, Ono H, Maitra A

PMID: 20703831 [PubMed - as supplied by publisher]

Imaging findings in a case of mixed acinar-endocrine carcinoma of the pancreas.

Fetched: August 17th, 2010, 9:13am CDT

Imaging findings in a case of mixed acinar-endocrine carcinoma of the pancreas.

Korean J Radiol. 2010 May-Jun;11(3):378-81

Authors: Chung WJ, Byun JH, Lee SS, Lee MG

PMID: 20461195 [PubMed - indexed for MEDLINE]

Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.

Fetched: August 17th, 2010, 9:13am CDT

Spontaneous infarction of pleomorphic adenoma: report of a case simulating malignancy on fine-needle cytology sample.

Diagn Cytopathol. 2010 Jun;38(6):430-4

Authors: Fulciniti F, Losito NS, Botti G, Manola M, Ionna F

PMID: 19894261 [PubMed - indexed for MEDLINE]

A case of acinar cell carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration prior to surgical treatment.

Fetched: August 10th, 2010, 6:31pm CDT

A case of acinar cell carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration prior to surgical treatment.

Nippon Shokakibyo Gakkai Zasshi. 2010 Aug;107(8):1328-34

Authors: Mataki Y, Shinchi H, Kurahara H, Maemura K, Minami K, Setoyama T, Ueno S, Sakoda M, Yamamoto T, Takao S, Natsugoe S

PMID: 20693758 [PubMed - in process]

Acinic Cell Carcinoma of Minor Salivary Glands: A Clinical and Immunohistochemical Study.

Fetched: August 4th, 2010, 9:26am CDT

Acinic Cell Carcinoma of Minor Salivary Glands: A Clinical and Immunohistochemical Study.

J Oral Maxillofac Surg. 2010 Jul 31;

Authors: Triantafillidou K, Iordanidis F, Psomaderis K, Kalimeras E

PURPOSE: Acinic cell carcinoma is a rare malignant tumor of salivary glands. The purpose of this study is to evaluate the clinical outcome of acinic cell carcinoma in a group of 11 patients, who were treated in our clinic, and to discuss the management as well as the immunohistochemical features and prognosis of this carcinoma. MATERIALS AND METHODS: The study included 11 patients with acinic cell carcinoma of the minor salivary glands who were treated in our clinic. The patients were 7 women and 4 men. The patients' age ranged from 46 to 83 years. The distribution of the primary sites was buccal mucosa (4) maxilla/maxillary sinus, etc, (2), hard palate (1), junction of soft/hard palate (1), lower lip (1), labio marginal sulcus (1), and vestibular sulcus and mandible (1). All patients were treated with surgery. Adjuvant radiotherapy was used in 3 patients. Immunohistochemical assay of expression of Ki-67, p53, EGFR, and c-erbB-2/neu markers was performed on specimens of all tumors. RESULTS: The mean follow-up range was 2 to 15 years. Of the 11 patients, 7 were alive (2, 3, 4, 5, and 15 years after the initial therapy). Two patients died of another cause free of the disease 9 and 10 years after the initial treatment, and 2 patients died of the disease (local recurrence, distant metastases 2 and 3 years later). Overexpression of immunohistochemical markers was evident for tumors with widespread metastases. CONCLUSIONS: Acinic cell carcinoma is a rare malignant tumor of the salivary glands, characterized by an indolent clinical course with the potential for both local recurrence and distant metastases. The immunohistochemical analysis of proliferation markers provides additional prognostic information for this tumor.

PMID: 20678839 [PubMed - as supplied by publisher]

[Clinical and pathological analysis of 114 cases with non-ductal pancreatic adenocarcinoma occupying lesions]

Fetched: August 4th, 2010, 9:26am CDT

[Clinical and pathological analysis of 114 cases with non-ductal pancreatic adenocarcinoma occupying lesions]

Zhonghua Yi Xue Za Zhi. 2010 Apr 27;90(16):1089-92

Authors: Wang Y, Xie SL, Wang CF, Liu SM, Shan Y, Zhao DB, Liu Q, Luo W, Zhao P

PMID: 20646423 [PubMed - in process]

Cytology and histology have limited added value in prognostic models for salivary gland carcinomas.

Fetched: August 4th, 2010, 9:26am CDT

Cytology and histology have limited added value in prognostic models for salivary gland carcinomas.

Oral Oncol. 2010 Jul 14;

Authors: van der Schroeff MP, Terhaard CH, Wieringa MH, Datema FR, Baatenburg de Jong RJ

Univariate analyses on malignant salivary gland tumors report a strong relation of histological subtypes and prognosis. However, multivariate analyses with sufficient patients and reflecting the broad spectrum of putative prognostic factors are rare. In order to study the prognostic value of cytology and histology in salivary carcinoma we performed multivariate analyses on 666 newly diagnosed patients. In multivariate analyses sex, tumor size, N- and M-staging, localization, comorbidity, skin involvement and pain were independent predictors of survival. Histology was an independent prognostic factor, mainly because acinic cell carcinoma acted differently from the other histological subtypes. However, a simple prognostic model without cytology and/or histology has similar predictive power compared to more elaborate models. The added prognostic value of cytology and/or histology factors in salivary carcinoma is limited, largely due to the combined prognostic value of other prognostic factors such as tumor size, N- and M-classification and comorbidity.

PMID: 20637682 [PubMed - as supplied by publisher]

Primary acinic cell carcinoma of the ethmoid sinus.

Fetched: August 4th, 2010, 9:26am CDT

Primary acinic cell carcinoma of the ethmoid sinus.

Ear Nose Throat J. 2010 Jul;89(7):E40-1

Authors: Wong A, Leong JL, Ho B

PMID: 20628981 [PubMed - in process]

Mayo Clinic Experience With Very Rare Exocrine Pancreatic Neoplasms.

Fetched: August 4th, 2010, 9:26am CDT

Mayo Clinic Experience With Very Rare Exocrine Pancreatic Neoplasms.

Pancreas. 2010 Jul 7;

Authors: Mansfield A, Tafur A, Smithedajkul P, Corsini M, Quevedo F, Miller R

PMID: 20622706 [PubMed - as supplied by publisher]

Survival in oral cavity minor salivary gland carcinoma.

Fetched: August 4th, 2010, 9:26am CDT

Survival in oral cavity minor salivary gland carcinoma.

Otolaryngol Head Neck Surg. 2010 Jul;143(1):122-6

Authors: Kakarala K, Bhattacharyya N

OBJECTIVE: To describe the epidemiology and comparative survival for minor salivary gland cancer of the oral cavity. STUDY DESIGN: Historical cohort study. SETTING: Academic medical center. SUBJECTS AND METHODS: Cases of minor salivary gland cancer of the oral cavity were extracted from the Surveillance, Epidemiology, and End Results database (1988-2005) and staged. Kaplan-Meier survivals were compared according to histology as well as T stage and N stage. A Cox proportional hazards model incorporating histology, T stage, N stage, age, and sex was analyzed. RESULTS: A total of 639 salivary gland cancers of the oral cavity (55% female; mean age, 56 years) were identified with complete staging information, consisting of 318 mucoepidermoid, 169 adenoid cystic, 139 adenocarcinoma, and 14 acinic cell cancers. The hard palate and gums were the most common subsites involved (87.6%), followed by lip (7.2%) and tongue (5.2%). At presentation, T1 and T4 tumors predominated (42.6% and 35.2%, respectively); 93.4 percent were N0. Overall mean survival (months) was 157.9 and was similar across histologic subtypes: mucoepidermoid (172.4), adenoid cystic (141.4), acinic cell (138.7), and adenocarcinoma (147.2). Survival for low- and intermediate-grade mucoepidermoid carcinoma (171.0 and 182.3, respectively) was better than survival for high-grade mucoepidermoid carcinoma (50.3, P < 0.001). On multivariate analysis, N stage (P < 0.001) was the most powerful predictor of survival, along with T stage (P = 0.013), age (P < 0.001), and sex (P < 0.001). CONCLUSION: T stage and N stage are the most powerful predictors of survival in minor salivary gland carcinoma of the oral cavity. With the exception of high-grade mucoepidermoid carcinoma, survival for these lesions is generally favorable.

PMID: 20620630 [PubMed - in process]

Rare histological patterns of prostatic ductal adenocarcinoma.

Fetched: August 4th, 2010, 9:26am CDT

Rare histological patterns of prostatic ductal adenocarcinoma.

Pathology. 2010 Jun;42(4):319-24

Authors: Lee TK, Miller JS, Epstein JI

PMID: 20438402 [PubMed - indexed for MEDLINE]

Distal pancreatectomy combined with celiac axis resection in treatment of carcinoma of the body/tail of the pancreas: a single-center experience.

Fetched: August 4th, 2010, 9:26am CDT

Distal pancreatectomy combined with celiac axis resection in treatment of carcinoma of the body/tail of the pancreas: a single-center experience.

Ann Surg Oncol. 2010 May;17(5):1359-66

Authors: Wu X, Tao R, Lei R, Han B, Cheng D, Shen B, Peng C

PMID: 20198445 [PubMed - indexed for MEDLINE]

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Fetched: August 4th, 2010, 9:26am CDT

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Skeletal Radiol. 2010 Jun;39(6):601-2

Authors: Takechi Y, Shinozaki T, Fukuda T, Asami K, Yanagawa T, Takagishi K

PMID: 20177674 [PubMed - indexed for MEDLINE]

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Fetched: August 4th, 2010, 9:26am CDT

Multiple subcutaneous inflammation, osteolysis, and polyarthritis.

Skeletal Radiol. 2010 Jun;39(6):581-2, 601-2

Authors: Takechi Y, Shinozaki T, Fukuda T, Asami K, Yanagawa T, Takagishi K

PMID: 20174794 [PubMed - indexed for MEDLINE]

Primary signet-ring carcinoma (SRC) of the lung: a population-based epidemiologic study of 262 cases with comparison to adenocarcinoma of the lung.

Fetched: August 4th, 2010, 9:26am CDT

Primary signet-ring carcinoma (SRC) of the lung: a population-based epidemiologic study of 262 cases with comparison to adenocarcinoma of the lung.

J Thorac Oncol. 2010 Apr;5(4):420-7

Authors: Ou SH, Ziogas A, Zell JA

PMID: 20130484 [PubMed - indexed for MEDLINE]

Parotidectomies in benign parotid tumours: "Sant Pau" surgical extension classification.

Fetched: August 4th, 2010, 9:26am CDT

Parotidectomies in benign parotid tumours: "Sant Pau" surgical extension classification.

Acta Otorrinolaringol Esp. 2010 Jan-Feb;61(1):1-5

Authors: Quer M, Pujol A, LeÃ³n X, LÃ³pez M, GarcÃa J, OrÃºs C, SaÃ±udo JR

PMID: 19962123 [PubMed - indexed for MEDLINE]

[Correlation of early phase contrast enhancement of multi-detector row computed tomography to tumor stroma of nodular solid lung adenocarcinoma]

Fetched: August 4th, 2010, 9:26am CDT

[Correlation of early phase contrast enhancement of multi-detector row computed tomography to tumor stroma of nodular solid lung adenocarcinoma]

Ai Zheng. 2008 Nov;27(11):1190-6

Authors: Wang Y, Liu XG, Liang MZ, Qin PX, Lin YJ, Yi XP

PMID: 19000452 [PubMed - indexed for MEDLINE]

Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma.

Fetched: July 11th, 2010, 1:34pm CDT

Beer and its non-alcoholic compounds: role in pancreatic exocrine secretion, alcoholic pancreatitis and pancreatic carcinoma.

Int J Environ Res Public Health. 2010 Mar;7(3):1093-104

Authors: Gerloff A, Singer MV, Feick P

PMID: 20617020 [PubMed - in process]

Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case.

Fetched: July 11th, 2010, 1:34pm CDT

Long-term survival after a repetitive surgical approach in a patient with acinar cell carcinoma of the pancreas and recurrent liver metastases: report of a case.

Surg Today. 2010 Jul;40(7):679-83

Authors: Suzuki A, Sakaguchi T, Morita Y, Oishi K, Fukumoto K, Inaba K, Takehara Y, Baba S, Suzuki S, Konno H

PMID: 20582524 [PubMed - in process]

Prognostic relevance of CA 19-9, CEA, CRP, and LDH kinetics in patients treated with palliative second-line therapy for advanced pancreatic cancer.

Fetched: July 11th, 2010, 1:34pm CDT

Prognostic relevance of CA 19-9, CEA, CRP, and LDH kinetics in patients treated with palliative second-line therapy for advanced pancreatic cancer.

Tumour Biol. 2010 Aug;31(4):351-7

Authors: Haas M, Laubender RP, Stieber P, Holdenrieder S, Bruns CJ, Wilkowski R, Mansmann U, Heinemann V, Boeck S

PMID: 20480409 [PubMed - indexed for MEDLINE]

Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation.

Fetched: July 11th, 2010, 1:34pm CDT

Sclerosing polycystic adenosis of the parotid gland: report of one case diagnosed by fine-needle cytology with in situ malignant transformation.

Diagn Cytopathol. 2010 May;38(5):368-73

Authors: Fulciniti F, Losito NS, Ionna F, Longo F, Aversa C, Botti G, Foschini MP

PMID: 19937766 [PubMed - indexed for MEDLINE]

Acinic Cell Carcinoma of Minor Salivary Glands: A Clinicopathologic Study of 21 Cases.

Fetched: June 26th, 2010, 9:50am CDT

Acinic Cell Carcinoma of Minor Salivary Glands: A Clinicopathologic Study of 21 Cases.

J Oral Maxillofac Surg. 2010 Jun 22;

Authors: Omlie JE, Koutlas IG

PURPOSE: Acinic cell carcinoma (ACC) is an infrequent type of malignant salivary gland tumor. Approximately 16% of all ACCs occur in the mouth according to several small studies. This study was undertaken to 1) report on the clinicopathologic characteristics of 21 intraoral examples, 2) reconfirm the reported indolent behavior of these tumors, and 3) verify the synchronous or metachronous occurrence of other malignancies with ACC. MATERIALS AND METHODS: Twenty-one patients with intraoral ACC were identified in the previous 27 years. Demographic data and histomorphologic characteristics were evaluated and follow-up information was sought. RESULTS: Fifteen patients (68%) were male and 6 female. Seven cases (33.3%) occurred in the buccal mucosa, 6 in the palate (28.6%), 5 involved the upper lip (23.8%), 2 the retromolar mucosa (9.5%), and 1 the lower lip (4.8%). The mean age of patients was 50 years, with the youngest being 13 and the oldest 73. The duration was known in 9 patients and varied from 4 months to longer than 15 years. The size of the tumors varied from 0.6 to 1.6 cm. Where reported, lesions were asymptomatic. Histologically, different patterns that included microcystic, papillary cystic, follicular and solid, and combinations of these types characterized the lesions. Follow-up information was obtained in 12 patients. Eleven patients did not report recurrence or metastatic disease. The follow-up extended from 10 months to 17 years. One patient had 2 recurrences due to erroneous diagnosis that led to inappropriate treatment. After properly diagnosed and treated, this patient has been free of tumor for 4 years. Of interest were the metachronous occurrence of lymphoma in 1 patient and the synchronous occurrence of renal cell carcinoma in another. CONCLUSION: This study confirms the indolent behavior of ACC of minor salivary glands and previous reports on the occasional synchronous or metachronous association of malignant salivary gland tumors with other malignancies.

PMID: 20576339 [PubMed - as supplied by publisher]

Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail.

Fetched: June 26th, 2010, 9:50am CDT

Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail.

Neoplasia. 2010 Mar;12(3):224-34

Authors: Choudhary R, Li H, Winn RA, Sorenson AL, Weiser-Evans MC, Nemenoff RA

PMID: 20234816 [PubMed - indexed for MEDLINE]

Pancreatic Ducts as an Important Route of Tumor Extension for Acinar Cell Carcinoma of the Pancreas.

Fetched: June 15th, 2010, 3:51pm CDT

Pancreatic Ducts as an Important Route of Tumor Extension for Acinar Cell Carcinoma of the Pancreas.

Am J Surg Pathol. 2010 Jun 8;

Authors: Ban D, Shimada K, Sekine S, Sakamoto Y, Kosuge T, Kanai Y, Hiraoka N

PMID: 20534994 [PubMed - as supplied by publisher]

[Hepatocellular carcinoma - from macroscopy to molecular pathology.]

Fetched: June 15th, 2010, 3:51pm CDT

[Hepatocellular carcinoma - from macroscopy to molecular pathology.]

Orv Hetil. 2010 Jun 13;151(24):982-9

Authors: Schaff Z, Kovalszky I, Lotz G, Kiss A

PMID: 20519181 [PubMed - in process]

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.

Fetched: June 15th, 2010, 3:51pm CDT

Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions.

J Mol Histol. 2009 Jun;40(3):189-99

Authors: Fu XM, Dai X, Ding J, Zhu BT

PMID: 19821078 [PubMed - indexed for MEDLINE]

Permalink for 'Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy'

Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy

Posted: July 1st, 2010, 9:00am CDT

Conditions: Head and Neck Cancer; Mucositis; Oral Complications of Radiation Therapy; Pain
Interventions: Drug: doxepin hydrochloride; Other: placebo
Sponsors: North Central Cancer Treatment Group; National Cancer Institute (NCI)
Not yet recruiting - verified June 2010

Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer

Posted: May 9th, 2009, 9:00am CDT

Conditions: Breast Cancer; Colorectal Cancer; Head and Neck Cancer; Lung Cancer; Prostate Cancer
Interventions: Other: laboratory biomarker analysis; Radiation: radiation therapy
Sponsor: Vanderbilt-Ingram Cancer Center
Completed - verified July 2010

Dasatinib in Treating Patients With Recurrent or Metastatic Malignant Salivary Gland Tumors

Posted: March 10th, 2009, 9:00am CDT

Condition: Head and Neck Cancer
Interventions: Drug: dasatinib; Genetic: gene expression analysis; Genetic: gene rearrangement analysis; Genetic: mutation analysis; Genetic: polymerase chain reaction; Genetic: polymorphism analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacogenomic studies
Sponsors: University of Chicago; National Cancer Institute (NCI)
Recruiting - verified July 2010

Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain

Posted: October 1st, 2007, 9:00am CDT

Condition: Cancer
Interventions: Drug: fentanyl sublingual spray; Other: questionnaire administration
Sponsor: Insys Therapeutics Inc
Recruiting - verified October 2008

Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer

Posted: July 10th, 2007, 9:00am CDT

Condition: Cancer
Interventions: Drug: cyclophosphamide; Other: laboratory biomarker analysis; Procedure: biopsy; Procedure: cryosurgery
Sponsors: Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified July 2009

KU alumna's outlook on life a positive influence she left behind - Lawrence Journal World

Posted: September 1st, 2010, 4:17am CDT

KU alumna's outlook on life a positive influence she left behind
Lawrence Journal World
She had battled adenoid cystic carcinoma, all the while striving to make the world around her a better place. By Andy Hyland When Stan Loeb tells people ...

KU grad left legacy of courage - University Daily Kansan

Posted: August 31st, 2010, 5:31pm CDT

KU grad left legacy of courage
University Daily Kansan
Roark was diagnosed with Adenoid Cystic Carcinoma during her sophomore year at the University. The cancer occurs in salivary glands, but can appear anywhere ...

Radiation After Surgery Improves Survival for Rare Type of Breast Cancer - HealthNewsDigest.com

Posted: August 31st, 2010, 10:57am CDT

Radiation After Surgery Improves Survival for Rare Type of Breast Cancer
HealthNewsDigest.com
Adenoid cystic carcinoma, a tumor type that represents less than 1 percent of all breast carcinomas, is generally treated with surgery alone — either ...

and more »

Adenoid cystic carcinoma of the peripheral lung: a case report - 7thSpace Interactive (press release)

Posted: August 26th, 2010, 6:57am CDT

Adenoid cystic carcinoma of the peripheral lung: a case report
7thSpace Interactive (press release)
Adenoid cystic carcinoma of the peripheral lung is a rare entity. We recently encountered a patient with adenoid cystic carcinoma. ...

Pathology Quiz Case 1: Diagnosis - Archives of Otolaryngology

Posted: August 16th, 2010, 1:23pm CDT

Pathology Quiz Case 1: Diagnosis
Archives of Otolaryngology
... nasopharyngeal mass should include squamous cell carcinoma and histologic variants, nasopharyngeal carcinoma, adenocarcinoma, adenoid cystic carcinoma, ...

Tork and Blue Suede Shoes at Skylands - Sparta Independent

Posted: August 16th, 2010, 11:24pm CDT

Sparta Independent

Tork and Blue Suede Shoes at Skylands
Sparta Independent
... his life turned upside down after being diagnosed a couple of years ago with adenoid cystic carcinoma, a rare slow growing form of head and neck cancer. ...

Tork and Blue Suede Shoes at Skylands - Township Journal

Posted: August 13th, 2010, 11:21pm CDT

Township Journal

Tork and Blue Suede Shoes at Skylands
Township Journal
... his life turned upside down after being diagnosed a couple of years ago with adenoid cystic carcinoma, a rare slow growing form of head and neck cancer. ...

Unlikely Friends Find Bond In Cancer Battle, Firefighting - NBC Philadelphia

Posted: July 28th, 2010, 10:42pm CDT

Unlikely Friends Find Bond In Cancer Battle, Firefighting
NBC Philadelphia
He was also undergoing treatment for a rare cancer called Adenoid Cystic Carcinoma. And it wasn't long before the teen and ex-marine leaned on each other as ...

and more »

Adenoid cystic carcinoma of the breast in the United States (1977-2006): a ... - 7thSpace Interactive (press release)

Posted: July 23rd, 2010, 12:45pm CDT

Adenoid cystic carcinoma of the breast in the United States (1977-2006): a ...
7thSpace Interactive (press release)
IntroductionAdenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive ...

Cancer overcome, next hurdle is triathlon - The Riverdale Press

Posted: July 14th, 2010, 12:21pm CDT

The Riverdale Press

Cancer overcome, next hurdle is triathlon
The Riverdale Press
Although Bakst had no symptoms, further tests confirmed that Bakst had a rare form of cancer — adenoid cystic carcinoma — that afflicts fewer than 1000 ...

Pleural Mesothelioma One of Few Thoracic Cancers to Spontaneously Regress - Asbestos.com

Posted: July 7th, 2010, 12:17pm CDT

Pleural Mesothelioma One of Few Thoracic Cancers to Spontaneously Regress
Asbestos.com
Of the five cases, two were pleural mesothelioma, two were primary lung cancer (squamous cell) and one was adenoid cystic carcinoma. ...

Local cancer survivor stays focused on her life, not fear - Williston Daily Herald

Posted: July 3rd, 2010, 5:10pm CDT

Williston Daily Herald

Local cancer survivor stays focused on her life, not fear
Williston Daily Herald
But it was a cancer called adenoid cystic carcinoma. Lee was shocked. "It kinda hits you weird, 'cause you're not sick," she said. ...

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The 2010 Sunday Mercury Wonderkids - Sunday Mercury

Posted: July 3rd, 2010, 9:53am CDT

The 2010 Sunday Mercury Wonderkids
Sunday Mercury
Ellis had adenoid cystic carcinoma – cancer in his neck which had spread across his face. He underwent operations and radiotherapy and was given the ...

Couple Raises $3M To Fight Rare Cancer - WCVB-TV

Posted: June 28th, 2010, 10:32am CDT

Couple Raises $3M To Fight Rare Cancer
WCVB-TV
BOSTON -- Marnie and Jeff Kaufman had four boys under 10 when the Needham woman was diagnosed with adenoid cystic carcinoma in 2004. She was 38 years old. ...

and more »

Tumour dad's charity bike ride - The Star

Posted: June 28th, 2010, 3:52am CDT

Tumour dad's charity bike ride
The Star
Dan Porter, aged 36, had just become a father for the first time when he was diagnosed with adenoid cystic carcinoma - a rare form of cancer which resulted ...

Rare cancer spurs Mokena family to action - Chicago Tribune

Posted: June 25th, 2010, 12:03am CDT

Rare cancer spurs Mokena family to action
Chicago Tribune
Alicia Almanza, 37, has lived with adenoid cystic carcinoma since the age of 18. The rare, slow-growing cancer ...

Cutaneous appendageal carcinomas increased 150% in United States since 1978 - HemOncToday

Posted: June 22nd, 2010, 5:40am CDT

Cutaneous appendageal carcinomas increased 150% in United States since 1978
HemOncToday
According to background data, only 62 cases of spiradenocarcinoma and adenoid cystic carcinoma and less than 100 cases of most other apocrine-eccrine ...

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Gophers runner endures cancer surgery, then thrives - Big Ten Network

Posted: June 16th, 2010, 10:04am CDT

Gophers runner endures cancer surgery, then thrives
Big Ten Network
Anderson's 2009 outdoor season ended abruptly after she was diagnosed with adenoid cystic carcinoma, a rare cancer. She had surgery to remove a tumor from ...

Pushed to be her best - Minneapolis Star Tribune

Posted: June 14th, 2010, 8:55pm CDT

Pushed to be her best
Minneapolis Star Tribune
Anderson's 2009 outdoor season ended abruptly after she was diagnosed with adenoid cystic carcinoma, a rare cancer. She had surgery to remove a tumor from ...

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Adenoid cystic carcinoma of the peripheral lung: a case report.

Fetched: September 1st, 2010, 9:30am CDT

Adenoid cystic carcinoma of the peripheral lung: a case report.

World J Surg Oncol. 2010 Aug 26;8(1):74

Authors: Kitada M, Ozawa K, Sato K, Hayashi S, Tokusashi Y, Miyokawa N, Sasajima T

ABSTRACT: Adenoid cystic carcinoma of the peripheral lung is a rare entity. We recently encountered a patient with adenoid cystic carcinoma. A 75-year-old woman showed a nodular lesion with 10mm in diameter in the right upper lung field on chest radiography. The diagnosis was unclear, but lung cancer could not be ruled out. Thoracoscopic biopsy was performed, and intraoperative pathological diagnosis revealed the carcinoma of the lung. We enforced upper lobectomy and mediastinal lymph node dissection to the patient. Histopathological examination revealed adenoid cystic carcinoma with a characteristic cribriform structure. Immunohistochemical examination revealed that the tumor cells were positive for thyroid transcription factor 1 (TTF-1), this tumor was diagnosed primary ACC of the lung.

PMID: 20796281 [PubMed - as supplied by publisher]

Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland.

Fetched: September 1st, 2010, 9:30am CDT

Expression and importance of zinc-finger transcription factor Slug in adenoid cystic carcinoma of salivary gland.

J Oral Pathol Med. 2010 Aug 3;

Authors: Tang Y, Liang X, Zhu G, Zheng M, Yang J, Chen Y

Background: It has been reported that zinc-finger transcription factor Slug plays a critical role in tumor proliferation and differentiation, relapse, invasion, metastasis, and decreased survival. However, there is little information on the expression and role of Slug in salivary adenoid cystic carcinoma (ACC). Method: Demographic variables and primary tumor site, dates of diagnoses, perineural invasion, local regional recurrence, and distant metastasis of 121 cases of salivary ACC treated at the Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University between 1996 and 2005 were retrieved. The Slug expression of all these cases was examined by immunohistochemical methods. The association between Slug expression and clinicopathological variables was analyzed using Chi-squared test, and the prognostic factors were examined by univariate and multivariate analyses. Results: Our data demonstrated that the positive expression of Slug was observed in 71.90% (87/121) of cases. Slug expression was significantly associated with tumor site, TNM stage, histological pattern, perineural invasion, local regional recurrence and distant metastasis of patients with ACC (P < 0.05). And Slug expression, local regional recurrence and distant metastasis were independent and significant prognostic factors in all patients. Conclusions: It is proposed that Slug may play an important role in the invasion and metastasis of ACC, and that Slug had the potential for one of the strong invasion and metastasis indicators at presentation of ACC patients.

PMID: 20738754 [PubMed - as supplied by publisher]

Beyond triple-negative breast cancer: the need to define new subtypes.

Fetched: September 1st, 2010, 9:30am CDT

Beyond triple-negative breast cancer: the need to define new subtypes.

Expert Rev Anticancer Ther. 2010 Aug;10(8):1197-213

Authors: Constantinidou A, Jones RL, Reis-Filho JS

Advances in the systemic treatment of early breast cancer have led to significant improvements in survival for patients with hormone receptor- and/or HER2-positive disease. In recent years, interest has focused on tumors that lack expression of the estrogen receptor, progesterone receptor and HER2, the so-called triple-negative subgroup. As a group, triple-negative cancers have a relatively aggressive clinical course, with early development of visceral metastases and a poor long-term prognosis. These tumors, however, encompass a wide range of subtypes with varying prognosis, including a number of special types with a good prognosis (e.g., adenoid cystic carcinomas and secretory carcinoma). There is considerable overlap between triple-negative and basal-like tumors; however, microarray studies have demonstrated that the overlap between basal-like and triple-negative cancers is not complete. The similarities between sporadic triple-negative cancers and tumors arising in BRCA1 mutation carriers and the fact that the majority of BRCA1 tumors display a triple-negative phenotype have led to studies demonstrating a potential loss of BRCA1 function in triple-negative cancers and offered potential therapeutic avenues for patients with these cancers. However, it should be noted that triple-negative breast cancers comprise a heterogeneous group of tumors. Understanding the molecular underpinning of distinct subgroups of these cancers is crucial for the identification of novel therapeutic targets and individualization of treatment for patients with triple-negative disease.

PMID: 20735307 [PubMed - in process]

Permalink for '[Combined chemotherapy with Cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma.]'

[Combined chemotherapy with Cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma.]

Fetched: September 1st, 2010, 9:30am CDT

[Combined chemotherapy with Cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma.]

Gan To Kagaku Ryoho. 2010 Aug;37(8):1545-8

Authors: Yamada T, Mouri H, Izumi K, Takeuchi S, Ohtsubo K, Yamashita K, Yasumoto K, Kitamura S, Yano S

We report a case of a 65-year-old man with metastatic primary cutaneous adenoid cystic carcinoma that was effectively treated by combination chemotherapy with cisplatin(CDDP)plus vinorelbine(VNR). He detected a tumor mass on the anterior surface of his left patella in 2003 and underwent a tumorectomy in October 2008. He was given a diagnosis of primary cutaneous adenoid cystic carcinoma with metastatic lesions to multiple lungs and left tibial bone and then given chemotherapy combining CDDP plus VNR as the first treatment in December 2008. By this treatment for six cycles, the lung metastatic tumors gradually reduced on chest CT. We reported the efficacy of combined treatment with CDDP plus VNR for primary cutaneous adenoid cystic carcinoma, because this clinical condition was very rare and the standard treatment has still not been established.

PMID: 20716883 [PubMed - in process]

Permalink for 'Comprehensive Analysis of the MYB-NFIB Gene Fusion in Salivary Adenoid Cystic Carcinoma: Incidence, Variability and Clinicopathological Significance.'

Comprehensive Analysis of the MYB-NFIB Gene Fusion in Salivary Adenoid Cystic Carcinoma: Incidence, Variability and Clinicopathological Significance.

Fetched: August 13th, 2010, 9:16pm CDT

Comprehensive Analysis of the MYB-NFIB Gene Fusion in Salivary Adenoid Cystic Carcinoma: Incidence, Variability and Clinicopathological Significance.

Clin Cancer Res. 2010 Aug 11;

Authors: Mitani Y, Li J, Rao PH, Zhao YJ, Bell D, Lippman SM, Weber RS, Caulin C, El-Naggar AK

PURPOSE: The objective of this study was to determine the incidence of the MYB-MFIB fusion in salivary adenoid cystic carcinoma (ACC), to establish the clinicopathological significance of the fusion and to analyze the expression of MYB in ACCs in the context of the MYB-NFIB fusion.EXPERIMENTAL DESIGN: We performed an extensive analysis involving 123 cancers of the salivary gland, including primary and metastatic ACCs, and non-ACC salivary carcinomas. MYB-NFIB fusions were identified by reverse transcription-PCR (RT-PCR) and sequencing of the RT-PCR products, and confirmed by fluorescence in situ hybridization. MYB RNA expression was determined by quantitative RT-PCR and protein expression was analyzed by immunohistochemistry.RESULTS: The MYB-NFIB fusion was detected in 28% primary and 35% metastatic ACCs, but not in any of the non-ACC salivary carcinomas analyzed. Different exons in both MYB and NFIB genes were involved in the fusions, resulting in expression of multiple chimeric variants. Notably, MYB was overexpressed in the vast majority of the ACCs, although MYB expression was significantly higher in tumors carrying the MYB-NFIB fusion. The presence of the MYB-NFIB fusion was significantly associated (p = 0.03) with patients older than 50 years of age. No correlation with other clinicopathological markers, factors and survival was found. CONCLUSIONS: We conclude that the MYB-NFIB fusion characterizes a subset of ACCs and contributes to MYB overexpression. Additional mechanisms may be involved in MYB overexpression in ACCs lacking the MYB-NFIB fusion. These findings suggest that MYB may be a specific novel target for tumor intervention in patients with ACC.

PMID: 20702610 [PubMed - as supplied by publisher]

Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.

Fetched: August 13th, 2010, 9:16pm CDT

Salivary gland tumors: immunohistochemical study of EGF, EGFR, ErbB-2, FAS and Ki-67.

Anal Quant Cytol Histol. 2009 Oct;31(5):280-7

Authors: Ito FA, Ito K, Coletta RD, Graner E, de Almeida OP, Lopes MA

OBJECTIVE: To analyze the expression of ErbB-1 (Her-1 or EGFR), ErbB-2 (Her-2 or neu), ErbB-3 (Her-3) and ErbB-4 (Her-4) and their correlation in 3 different types of salivary gland tumors. STUDY DESIGN: Immunohistochemical expression of epidermal growth factor (EGF), EGFR, ErbB-2, fatty acid synthase (FAS) and Ki-67 were analyzed in 41 pleomorphic adenoma (PA), in 30 mucoepidermoid carcinoma (MEC) and in 30 adenoid cystic carcinoma (ACC) and correlated with their histologic patterns. RESULTS: EGF was more common in MEC and PA, but MEC had a higher percentage of strongly positive cases. EGFRc and EGFRm were both more frequent in MEC and ACC. Higher scores of ErbB-2c were observed in PA, followed by MEC and ACC. In contrast, higher scores of ErbB-2m were more common in MEC as compared to ACC and PA. FAS was most commonly found in PA and MEC. Moreover, MEC showed the highest percentage of strongly positive cases. Ki-67 was higher in MEC and ACC than in PA. From a correlation of immunomarkers with the histologic patterns, it was observed that cribriform ACC presented more expression of EGFR and high grade MEC showed a higher percentage of ErbB-2, FAS and Ki-67. CONCLUSION: EGF, EGFR, ErbB-2 and FAS were commonly found and seem to be important in the tumorigenesis of salivary gland tumors, particularly in percentage of strongly positive cases. Ki-67 was higher in MEC and ACC than in PA. From a correlation of immunomarkers with the histologic patterns, it was observed that cribriform ACC presented more expression of EGFR and high grade MEC showed a higher percentage of ErbB-2, FAS and Ki-67. CONCLUSION: EGF, EGFR, ErbB-2 and FAS were commonly found and seem to be important in the tumorigenesis of salivary gland tumors, particularly in MEC. (Anal Quant Cytol Histol 2009;31:280-287)

PMID: 20701095 [PubMed - in process]

A balanced perspective for management of tracheal salivary gland-type carcinomas.

Fetched: August 13th, 2010, 9:16pm CDT

A balanced perspective for management of tracheal salivary gland-type carcinomas.

J Thorac Cardiovasc Surg. 2010 Aug;140(2):394

Authors: Denlinger CE

PMID: 20637918 [PubMed - indexed for MEDLINE]

Permalink for 'Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma.'

Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma.

Fetched: August 10th, 2010, 6:31pm CDT

Nerve growth factor and vascular endothelial growth factor: retrospective analysis of 63 patients with salivary adenoid cystic carcinoma.

Int J Oral Sci. 2010 Mar;2(1):35-44

Authors: Hao L, Xiao-lin N, Qi C, Yi-ping Y, Jia-quan L, Yan-ning L

AIM: To detect the expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) in salivary adenoid cystic carcinoma (SACC) tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC. METHODOLOGY: Medical records of 63 patients surgically treated for SACC between January 1988 and October 2005 were reviewed. Immunohistochemistry was performed to examine the expression of NGF and VEGF in tumor tissues. Kaplan-Meier analysis and Cox's proportional hazard regression model were applied to assess predictors of survival. RESULTS: NGF and VEGF were overexpressed in SACC tissues, compared with those in normal salivary tissues (P < 0.05), and the staining intensity of these two factors was stronger in groups of solid subtype, advanced TNM stage, perineural invasion and recurrence. Patients with high-expression of NGF and VEGF, solid subtype, advanced stage, perineural invasion, recurrence and extended resection alone had worse survival rates (P < 0.05). CONCLUSION: NGF and VEGF are expressed increasingly in the tissues of SACC cases with invasion and metastasis. NGF expression and VEGF expression are independent

PMID: 20690417 [PubMed - in process]

Permalink for 'Adenoid cystic carcinomas of the breast have low topoisomerase IIalpha expression but frequently overexpress epidermal growth factor protein without epidermal growth factor gene amplification.'

Adenoid cystic carcinomas of the breast have low topoisomerase IIalpha expression but frequently overexpress epidermal growth factor protein without epidermal growth factor gene amplification.

Fetched: August 10th, 2010, 6:31pm CDT

Adenoid cystic carcinomas of the breast have low topoisomerase IIalpha expression but frequently overexpress epidermal growth factor protein without epidermal growth factor gene amplification.

Hum Pathol. 2010 Aug 3;

Authors: Vranic S, Frkovic-Grazio S, Lamovec J, Serdarevic F, Gurjeva O, Palazzo J, Bilalovic N, Lee LM, Gatalica Z

Adenoid cystic carcinoma of the breast is a rare subtype of breast cancer with basal-like features. Published studies on breast adenoid cystic carcinoma are limited, resulting in relatively scarce information on the value of predictive tumor markers. We studied 20 primary cases of adenoid cystic carcinoma of the breast for expression of estrogen receptor, progesterone receptor, androgen receptor, epidermal growth factor receptor, HER-2/neu, and topoisomerase IIalpha using immunohistochemistry and fluorescent in situ hybridization methods. Estrogen and progesterone receptor expression were detected in 1 case each. All tumors were uniformly negative for Her-2/neu expression. Androgen receptor and topoisomerase IIalpha expression were weakly positive in three cases and 7 cases, respectively. Epidermal growth factor receptor overexpression was detected in 13 cases (65% of all cases). Amplification of TOP2A or HER-2/neu gene was not detected in any of the cases. Our study shows that the majority of adenoid cystic carcinomas of the breast do not overexpress Her-2/neu, topoisomerase IIalpha, or estrogen receptor, and thus, they are unlikely to respond to therapies targeting these proteins. However, these tumors frequently over-express epidermal growth factor receptor, indicating a potential benefit from anti-epidermal growth factor receptor therapy for patients with advanced adenoid cystic carcinomas of the breast.

PMID: 20688355 [PubMed - as supplied by publisher]

[Diagnosis and treatment of tracheal or bronchuotracheal adenoid cystic carcinoma]

Fetched: August 10th, 2010, 6:31pm CDT

[Diagnosis and treatment of tracheal or bronchuotracheal adenoid cystic carcinoma]

Zhongguo Fei Ai Za Zhi. 2010 Jun;13(6):628-31

Authors: Qin M, Fu Y, Yu D, Xu S, Han M, Wang Z

BACKGROUND AND OBJECTIVE: Adenoid cystic carcinoma is primary bronchopulmonary carcinoma with low malignancy, and 43 patients treated in the past 50 years in our hospital were retrospectively studied. The aim of this study is to discuss the clinical symptoms, pathologic characteristic and therapeutic method of primary tracheal or bronchuotracheal adenoid cystic carcinoma. METHODS: This study summarized total 43 patients of primary tracheal or bronchus adenoid cystic carcinoma treated in our hospital from Jan. 1958 to Dec. 2007. Among them, 40 patients were treated by surgical resection, and 3 patients were treated by fiberoptic bronchoscope's interventional treatment. RESULTS: The 1-yr, 3-yr, 5-yr survival rates of the 43 patients above were 100% (41/41), 89.5% (34/38), 87.1% (27/31), respectively. CONCLUSION: Primary tracheal or bronchus adenoid cystic carcinoma are rare and low malignancy carcinoma. The clinical symptoms of them are not typical. The best treatment is early detection and taking measures of operation plus radiotherapy. The other palliative treatment is fiberoptic bronchoscope's interventional treatment.

PMID: 20681452 [PubMed - in process]

Signaling pathways in adenoid cystic cancers: implications for treatment.

Fetched: August 10th, 2010, 6:31pm CDT

Signaling pathways in adenoid cystic cancers: implications for treatment.

Cancer Biol Ther. 2009 Oct;8(20):1947-51

Authors: Gupta AK, Wilke WW, Taylor EN, Bodeker KL, Hoffman HT, Milhem MM, Buatti JM, Robinson RA

Adenoid cystic cancers (ACC) in the head and neck are rare yet present a clinical dilemma. Although 5-y survivals are excellent, they have a propensity for late recurrences. Most of these cancers are initially treated with surgery followed by radiation. When recurrences happen, treatment options are limited both by the morbidity and low efficacy of re-irradiation and repeated surgical resection. Reported response rates to chemotherapy are low and targeted therapies may be one option. We, therefore, investigated signaling pathways that may be active in adenoid cystic cancers. Tissues from the last nine ACC patients resected at the University of Iowa were immunohistochemically stained with antibodies for EGFR, phosphorylated (P) Akt, and P-MAPK in order to molecularly characterize these tumors. An ACC cell line (ACC3) was also characterized by western blot. We found that seven of the nine tumor samples had strong expression of P-Akt and 5/9 had P-MAPK. None of them had EGFR expression. In the ACC3 cell line, similar data was found in that there was P-Akt and P-MAPK but no EGFR expression. We tested the HIV protease inhibitor nelfinavir (NFV) which has been shown to inhibit Akt signaling to see its effect on ACC3 cells. Both P-Akt and P-MAPK were inhibited with NFV in ACC3 cells and this resulted in growth inhibition and clonogenic death. In patients where re-irradiation or further surgery is not an option, a trial of NFV may be warranted.

PMID: 19729990 [PubMed - indexed for MEDLINE]

As(2)O(3) may be a treatment option for adenoid cystic carcinoma of salivary gland.

Fetched: August 4th, 2010, 9:26am CDT

As(2)O(3) may be a treatment option for adenoid cystic carcinoma of salivary gland.

Med Hypotheses. 2010 Jul 23;

Authors: Fu ZC, Zhang B, Fu ZJ

Adenoid cystic carcinoma (ACC) is an uncommon tumor of the head and neck that may occur in any salivary gland tissue. Discouraging treatment outcomes may be related to perineural spread, loco regional invasion, and an unusually high incidence of metastatic potential [1]. It presents a number of challenges related to facial nerve management and disease extension into surrounding soft tissue and bony compartments [2]. ACC mostly occurring in the major and minor salivary glands, has some unique characteristics such as slow growth, diffuse invasion, and high incidence of distant metastasis [3]. It is a high malignant carcinoma characterized by intensive local invasion and insidious distant metastasis to the lung at an early stage, which is responsible for a poor long-term survival rate [4]. The main clinical treatment to adenoid cystic carcinoma depended on surgical operation in the past. However, it was not so easy to completely excise adenoid cystic carcinoma which resulting in the residual of tumor cells. Therefore, radiotherapy was often used after the operation. Radiotherapy alone cannot achieve the goal of radical cure, but operation combined with radiotherapy can evidently reduce the post-operative recurrence rate and increase the survival rate. Adenoid cystic carcinoma is not sensitive to conventional chemotherapeutics, so it is necessary to explore a new kind of drug which possesses inhibition and killing effects to this tumor. Arsenic trioxide (A(S2)O(3), ATO), a trivalent inorganic arsenite, has been proved to be an effective therapeutic agent against acute promyelocytic leukemia [8]. Numerous reports have revealed that arsenite exerts its therapeutic activity by induction of apoptosis. It also induces apoptosis in a variety of cancer cells over a wide dose range. A(S2)O(3) may become a treatment option for adenoid cystic carcinoma of salivary gland.

PMID: 20656411 [PubMed - as supplied by publisher]

Adenoid cystic carcinoma of the breast in the United States (1977-2006): a population-based cohort study.

Fetched: August 4th, 2010, 9:26am CDT

Adenoid cystic carcinoma of the breast in the United States (1977-2006): a population-based cohort study.

Breast Cancer Res. 2010 Jul 23;12(4):R54

Authors: Ghabach B, Anderson WF, Curtis RE, Huycke MM, Lavigne JA, Dores GM

ABSTRACT: INTRODUCTION: Adenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive data exists. We sought to provide new population-based information on breast-ACC incidence, relative survival, and associated cancer risk in the United States. METHODS: Using data from the Surveillance, Epidemiology and End Results Program, we calculated age-adjusted incidence rates (IRs), IR ratios (IRRs), and relative survival (RS) for breast-ACC, and standardized incidence ratios (SIRs) for other cancers. RESULTS: Overall 338 women (IR=0.92/one-million person-years) were diagnosed with breast-ACC during 1977 to 2006. Blacks had 39% lower IRs than Whites (IRR=0.61, 95%CI=0.37 to 0.96), and IRs remained constant over the 30-year period. Ninety-five percent of cases presented with localized stage (n=320; IR=0.87), and the highest IRs were observed for estrogen receptor (ER)-negative/progesterone receptor (PR)-negative tumors (IR=0.56). Like other typically ER-negative tumors, age-specific IRs increased until midlife then plateaued. Five-, 10-, and 15-year RS was 98.1%, 94.9%, and 91.4%, respectively. The risk of female breast cancer was not increased following (SIR=0.89, 95%CI=0.43 to 1.64) or preceding (SIR=0.71, 95%CI=0.28 to 1.46) breast-ACC. Similarly, no association was observed for breast-ACC and risk of all other cancers combined, solid tumors, or lymphohematopoietic malignancies. CONCLUSIONS: Breast-ACC among women is characterized by ER-negative/PR-negative expression, rare regional lymph node involvement, a favorable prognosis with excellent survival, and absence of associated cancers. These findings reinforce the importance of tailored treatments for breast-ACC and lend credence to the apparent heterogeneity of basal-like breast cancers.

PMID: 20653964 [PubMed - as supplied by publisher]

Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: A review.

Fetched: August 4th, 2010, 9:26am CDT

Chemotherapy and targeted therapy in adenoid cystic carcinoma of the head and neck: A review.

Head Neck. 2010 Jul 22;

Authors: Papaspyrou G, Hoch S, Rinaldo A, Rodrigo JP, Takes RP, van Herpen C, Werner JA, Ferlito A

Adenoid cystic carcinoma (ACC) is an uncommon tumor usually arising in the head and neck region, mainly in the salivary glands. It demonstrates an indolent prolonged course and is characterized by perineural invasion. Primary treatment of local and locoregional disease consists mainly of surgery and/or irradiation. During follow-up these patients frequently develop local recurrences and distant metastases, especially in the lung, although long-term survival is possible. The role of chemotherapy in ACC is limited, and studies with only a limited number of patients are performed. In this article we review the literature on chemotherapy regimens, including monotherapy and combination chemotherapy schedules, as well as the new targeted therapies. (c) 2010 Wiley Periodicals, Inc. Head Neck, 2010.

PMID: 20652885 [PubMed - as supplied by publisher]

Sublingual gland tumors: Clinical, pathologic, and therapeutic analysis of 13 patients treated in a single institution.

Fetched: August 4th, 2010, 9:26am CDT

Sublingual gland tumors: Clinical, pathologic, and therapeutic analysis of 13 patients treated in a single institution.

Head Neck. 2010 Jul 19;

Authors: Zdanowski R, Dias FL, Barbosa MM, Lima RA, Faria PA, Castro AL, Souza KC

BACKGROUND.: Sublingual gland tumors are rare, although frequently malignant. This study describes the clinicopathologic features and treatment results and reviews the literature. METHODS.: Thirteen cases treated between 1996 and 2007 were reviewed with interest on clinical, pathologic, and therapeutic information. Survival data were calculated by the Kaplan-Meier method. RESULTS.: Malignancies represented 92.3% of cases. Adenoid cystic carcinoma was the most common malignant type (66.7%). Most patients (83.3%) presented in advanced pathologic TNM stages (III or IV). All cases underwent surgical treatment. Neck dissection was performed in 69.2% with no metastases detected. Ten patients (83.3%) had adjuvant radiotherapy. Distant metastases occurred in 3 patients (25%). The 5-year overall and disease-free survival rates were 78.7% and 87.5%, respectively. CONCLUSIONS.: Tumors of the sublingual gland are rare and are usually malignant. Radical surgery and adjuvant radiotherapy seems to offer adequate local and regional control. Unlike distant failure, local recurrence and regional metastases are not common. (c) 2010 Wiley Periodicals, Inc. Head Neck, 2010.

PMID: 20645286 [PubMed - as supplied by publisher]

Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis.

Fetched: August 4th, 2010, 9:26am CDT

Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis.

Oral Oncol. 2010 Jul 14;

Authors: Ota T, Ota K, Jono H, Fujimori H, Ueda M, Shinriki S, Sueyoshi T, Shinohara M, Ando Y

The aims of this study were to investigate midkine (MK) expression patterns in salivary gland tumors (SGTs) and to evaluate the correlation between MK expression and the degree of malignancy. We performed immunohistochemistry to examine MK expression in specimens of adenoid cystic carcinoma (ACC), mucoepidermoid carcinoma (MEC), and pleomorphic adenoma (PA). In addition, we performed immunohistochemistry for CD31 and measured microvessel density (MVD), which is an indicator of angiogenesis. Immunohistochemistry showed that MK protein expression was significantly higher in specimens of malignant SGTs (ACC [P<0.01] and MEC [P<0.001]) than in benign SGT (PA) samples. Furthermore, MVD values tended to be higher in cases that exhibited high expression of MK, which indicated a significant correlation between the degree of MK expression and MVD (P<0.001). These results suggest that MK may play important roles in malignant transformation and tumor angiogenesis in SGTs.

PMID: 20637680 [PubMed - as supplied by publisher]

[Role of Survivin gene on the apoptosis of adenoid cystic carcinoma-2 cells induced by arsenic trioxide]

Fetched: August 4th, 2010, 9:26am CDT

[Role of Survivin gene on the apoptosis of adenoid cystic carcinoma-2 cells induced by arsenic trioxide]

Hua Xi Kou Qiang Yi Xue Za Zhi. 2010 Jun;28(3):246-9

Authors: Zhang B, Mu HB, Xu XG, Liu W, Hu NR

OBJECTIVE: To investigate the proliferation effects of arsenic trioxide (As2O3) on salivary adenoid cystic carcinoma-2 (ACC-2) cells in vitro and to study the role of Survivin on the apoptosis of ACC-2 induced by As2O3. METHODS: ACC-2 cells were treated with different concentration of As2O3 for different time. The inhibitory effects on cell's viability were assayed with methyl thiazolyl tetrazolium (MTT) test. Apoptosis was determined by flow cytometry. The expression of Survivin mRNA and protein were investigated by reverse transcription-polymerase chain raction (RT-PCR) and Western blot analysis respectively. RESULTS: Cell viability after As2O3 treatment was markedly suppressed and exhibited as a dose- and time-dependent pattern. The apoptotic index showed the similar trend. The results of RT-PCR revealed gene expression of Survivin was suppressed significantly. Through Western blot analysis, a negative correlation between concentration and amount of protein product of Survivin was determined. CONCLUSION: As2O3 might markedly suppressed ACC-2 cell's viability in vitro. The inhibition of Survivin gene expression may play a critical role on ACC-2 cell apoptosis induced by As2O3.

PMID: 20635649 [PubMed - in process]

[Effect of Matrine on cell cycle and human telomerase reverse transcriptase of human salivary adenoid cystic carcinoma]

Fetched: August 4th, 2010, 9:26am CDT

[Effect of Matrine on cell cycle and human telomerase reverse transcriptase of human salivary adenoid cystic carcinoma]

Hua Xi Kou Qiang Yi Xue Za Zhi. 2010 Jun;28(3):234-6, 240

Authors: Zhao JF, Xie WH, Li XM, Chen WT, Sun ML, Fang Z, Sun Q

OBJECTIVE: To investigate the effect of the traditional Chinese medicine Matrine on cell cycle and human telomerase reverse transcriptase (hTERT) of human ACC-M cell lines. METHODS: Different concentrations of Matrine were used in the medium of ACC-M cells. Change of cell cycle were detected by flow cytometry after ACC-M cell were cultivated with different concentrations Matrine (0.25, 0.50, 0.75, 1.00 mg x mL(-1)). Expression of hTERT was investigated by reverse transcription-polymerase chain reaction (RT-PCR) and indirect immunofluorescene and flow cytometry quantitative analysis. RESULTS: Matrine caused obviously the GdG1 phase block and inhibited proliferation of ACC-M cells. At same time, this effect was positive correlation to Matrine concentration and treat time. Matrine can inhibit the expression of hTERT mRNA and protein. CONCLUSION: Matrine can obviously inhibit cell cycle and down-regulate expression of hTERT. Inhibition of cell cycle is possible correlation with down-regulation expression of hTERT.

PMID: 20635646 [PubMed - in process]

Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.

Fetched: August 4th, 2010, 9:26am CDT

Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells.

Anticancer Drugs. 2010 Aug;21(7):678-86

Authors: Zhang S, Wang XL, Gan YH, Li SL

Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, originally developed for lowering cholesterol. Statins also have pleiotropic effects, independent of cholesterol-lowering effects, including induction of apoptosis in various cell lines. However, the mechanism underlying statin-induced apoptosis is still not fully understood. This study aims to explore the proapoptotic effects and underlying mechanisms of statins on human salivary adenoid cystic carcinoma (SACC). Exposure of SACC cells to mevastatin resulted in cell growth inhibition and apoptosis in a dose-dependent manner, accompanied by the release of cytochrome c and cleavage of caspase-3. A remarkable decrease in phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and increase in phosphorylation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated kinase were observed. Furthermore, the JNK-specific inhibitor SP600125, but not the p38-specific inhibitor SB203580, abolished mevastatin-induced cell growth inhibition and apoptosis in SACC cells. This was supported by results in which the JNK inhibitor efficiently blocked mevastatin-induced JNK phosphorylation, but not p38 phosphorylation, and further decreased mevastatin-induced phosphorylation of ERK1/2. Taken together, the results suggest that the JNK pathway was required for mevastatin-induced cell growth inhibition and apoptosis in SACC cells. Statins could be potential anticancer agents for SACC chemotherapy.

PMID: 20629200 [PubMed - in process]

Survival in oral cavity minor salivary gland carcinoma.

Fetched: August 4th, 2010, 9:26am CDT

Survival in oral cavity minor salivary gland carcinoma.

Otolaryngol Head Neck Surg. 2010 Jul;143(1):122-6

Authors: Kakarala K, Bhattacharyya N

PMID: 20620630 [PubMed - in process]

Tender tumor of the scalp: clinicopathologic challenge. Primary cutaneous adenoid cystic carcinoma.

Fetched: August 4th, 2010, 9:26am CDT

Tender tumor of the scalp: clinicopathologic challenge. Primary cutaneous adenoid cystic carcinoma.

Int J Dermatol. 2010 Jun;49(6):605-7

Authors: Torres T, Caetano M, Alves R, Horta M, Selores M

PMID: 20618463 [PubMed - in process]

Dermal cylindroma of the scalp (turban tumour) and subjacent calvarian defects.

Fetched: August 4th, 2010, 9:26am CDT

Dermal cylindroma of the scalp (turban tumour) and subjacent calvarian defects.

Anticancer Res. 2010 May;30(5):1793-7

Authors: Friedrich RE

This case report describes the diagnosis and therapy of a patient with a 40-year history of multiple potato-like tumours growing in the head and neck region. The tumour proved to be a cylindroma, associated with calvarian defects. Further facial tumours were diagnosed as trichoepitheliomas. This association of findings was pathognomonic for Brooke-Spiegler's syndrome. Complete work-up of the resection specimen excluded any malignant transformation of the tumour. A long lasting history of cylindroma and evidence for bone destruction, not associated with a malignant transformation, is extremely rare in Brooke-Spiegler's syndrome.

PMID: 20592381 [PubMed - indexed for MEDLINE]

Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract.

Fetched: August 4th, 2010, 9:26am CDT

Human papillomavirus-associated squamous cell carcinoma of the upper aerodigestive tract.

Am J Surg Pathol. 2010 Jul;34(7):e15-24

Authors: Stelow EB, Jo VY, Stoler MH, Mills SE

The association of human papillomavirus with the development of head and neck squamous cell carcinomas has been better elucidated over the past 20 years. In this review article, we examine the role of the virus in the development of these tumors. We discuss the clinical and pathologic features of human papillomavirus-associated squamous cell carcinomas of the head and neck. Immunohistochemical findings and those of other ancillary techniques are also reviewed. We further review the prognosis and treatment of these tumors. Finally, a detailed discussion is provided regarding the differential diagnosis that must be considered when confronting these squamous neoplasms.

PMID: 20534998 [PubMed - indexed for MEDLINE]

Unknown: A woman with an erythematous nodule on the scalp.

Fetched: August 4th, 2010, 9:26am CDT

Unknown: A woman with an erythematous nodule on the scalp.

Dermatol Online J. 2010;16(4):12

Authors: Aneiros-Fernandez J, Husein-ElAhmed H, Arias-Santiago S, Nicolae A, O'Valle-Ravassa F

A 77-year-old healthy woman presented with an isolated exophytic lesion of the scalp for 4 years, which had grown progressively. On exam, there was a 4 cm, firm erythematous and lobulated tumor with telangiectasias on the scalp. The rest of her cutaneous exam was normal. No lymphadenopathy was appreciated. A solitary cylindroma was diagnosed by biopsy.

PMID: 20409419 [PubMed - indexed for MEDLINE]

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